Abstract
We report a novel intramolecular 1,6 oxa-Michael addition on substituted dihydropyridines to obtain 5 and 6 member ring lactones in an one-pot reaction starting from activated pyridinyl propenones, without organic catalysis or presence of bulky groups in the Michael acceptor. A marked dependence on the regioselectivity of ring closure was found, dependent on the propenone used. 

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Background: Epilepsy is a brain disease characterized by a neuronal predisposition to generate epileptic seizures, all patients treated must follow the guidelines of the clinical record and have a reference and counter-reference system.