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Regiodivergent synthesis of vinyl trifluoromethansulfonates γ/δ lactones: Via 1,6 addition/intramolecular one-pot annulation of 1,4-dihidropyridines derivated from pyridinyl propenones

Abstract
We report a novel intramolecular 1,6 oxa-Michael addition on substituted dihydropyridines to obtain 5 and 6 member ring lactones in an one-pot reaction starting from activated pyridinyl propenones, without organic catalysis or presence of bulky groups in the Michael acceptor. A marked dependence on the regioselectivity of ring closure was found, dependent on the propenone used. 

Description of the referral centers for patients with epilepsy for the implementation of the TeleECHO project in a national institute of health

Abstract

Background: Epilepsy is a brain disease characterized by a neuronal predisposition to generate epileptic seizures, all patients treated must follow the guidelines of the clinical record and have a reference and counter-reference system.

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