Deep Brain Stimulation Neuromodulation for the Treatment of Mood Disorders: Obsessive Compulsive Disorder and Treatment Resistant Depression

Abstract
Mood disorders like major depressive (MDD) and obsessive compulsive (OCD) disorders affects 300 million people worldwide, and 20–30% are refractory to drug therapy (1). OCD could lead to a lifetime of disabling symptoms while treatment resistant depression (TRD) could lead to suicidal attempts (2, 3). Symptoms common to both disorders include anxiety, sleep disturbances and disruption of selective attention, in contrast to the obsessive thinking and compulsive behavior in OCD, and guilt, concentration problems, sadness and passive behavior in MDD [...]